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Nefrologia clinica

PREDICTION OF GLOMERULAR FILTRATION RATE FROM SERUM CONCENTRATION OF CYSTATIN C: COMPARISON OF TWO ANALYTICAL METHODS

poster

Background

The aim of this study was to compare two methods used to measure  serum cystatin C (Cys), and their accuracy to predict glomerular filtration rate (GFR).

Patients and Methods

Three hundred-sixty seven adult chronic kidney disease (CKD) patients with different functional impairment participated to this study. GFR was determined as the renal clearance of99mTc-DTPA. Serum concentrations of cystatin C (SCys) were determined with an immunonephelometric method and with an immunoturbidimetric method.

Results

A very high linear correlation was found between the two measurements of SCys (r=0.929). The mean difference SCysTurb-SCysNeph was 0.02±0.43 mg/L (NS). A high logarithmic correlation was also found between SCys and GFR (r was 0.919 for SCysNeph and 0.937 for SCysTurb). By means of multiple regression analysis, we developed formulas to predict GFR from SCysNeph, SCysTurb, and  SCr. For comparison, GFR was predicted using published formulas. A good agreement was found between predicted  GFR and measured GFR. The accuracy of SCysNeph, SCysTurb and SCreat, and of the different prediction formulas resulted quite similar.

Conclusion

The immunoturbidimetric method seems adequate to measure SCys  and to predict GFR and its impairment in CKD, at least like the immunonephelometric method. The accuracy of SCys and of derived formulas was not higher than that of SCr and SCr-based formulas.

release  1
pubblicata il  27 settembre 2012 
da Donadio Carlo¹, Olivieri Luigi²
(¹Dipartimento di Medicina Interna, Unità di Nefrologia, Università di Pisa, Pisa; ²Laboratorio Analisi Chimico-Cliniche Specialistiche, Azienda Ospedaliero Universitaria, Pisa, Italy)
Parole chiave: funzione renale
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Realizzazione: Tesi S.p.A.

Per assistenza contattare: Claudia Ingrassia, Tesi S.p.A.
0172 476301 — claudia.ingrassia@gruppotesi.com