AKI is seen as a continuum, from a very early stage of increased susceptibility to insults to the final stages of kidney damage. Atseveral points, the process can be slowed down, arrested or even reversed. NGAL can play a major role in several points of the acute kidney injury continuum predicting AKI, helping prevention and protection, stratifying for severity, assessing the need for renal replacement therapy, guiding the therapy and suggesting optimal start and stop of therapy, discriminating between recovery or progression towards CKD.
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